Biomaterials and Multiscale Mechanics Group

Post Doc

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  Chandra Khatua

  Chandra Khatua, Postdoctoral Fellow from June 2021, Centre of Nanotechnology, IIT Roorkee. Her research area is focused on polymer and ceramic based biomaterials for drug delivery and orthopaedic application. She has completed her Bachelor (2010) in Chemistry and B.Tech. (2013) in Polymer Science and Technology from University of Calcutta. She has received M.Tech.(2015) in Glass and Ceramic Engineering and PhD (2019) from CSIR-CGCRI (AcSIR). Her doctoral research was based on bioactive glass and self-setting ceramic composites for bone implant application. She worked as a research professor at Korea University, South Korea (2019-2020). She worked for Forevision Instruments Pvt. Ltd as a Scientific Operator at Jawaharlal Nehru Centre For Advanced Scientific Research (2019-2020).

Ph.D

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  Anshu Dubey

  Ms.Anshu Dubey Research Scholar, Department of Metallurgical and Materials Engineering at Indian Institute of Technology, Roorkee. She obtained her Master Degree in Materials Engineering at NIT, Nagpur. 2015 and B.Tech in Mechanical Engineering from Rajiv Gandhi Prodyogiki Vishwavidyalaya, Bhopal, India in 2012. Her M.Tech Thesis work focused on the Fatigue Behaviour of CFC Composite material and has 1 publication from this work. She has received Academic Excellence award and certificate from Governor of Maharashtra during her Mtech program. Presently, she is working on magnesium based alloys for Orthopaedic Applications.

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  Satish Jaiswal

  Satish Jaiswal is a PhD student in the department of Metallurgical and Materials Engineering at IIT Roorkee. He received his B.Tech degree with honors in Mechanical Engineering from Dr. K. N. Modi institute of Engineering and Technology, India in 2013. His B.Tech Project work focused on the optimization of heat evolution in hydraulic disc brake system. He worked on Magnesium based material system for orthopedic application during his M.Tech dissertation from IIT Roorkee.

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  Vaibhav Jain

  Vaibhav Jain is a PhD student in the department of Metallurgical and Materials Engineering at IIT Roorkee. He received his B.E degree in Production and Industrial Engineering from MBM Engineering College Jodhpur, Rajasthan, India in 2013. His B.E Project project was Machine Vision, which is basically an industrial automation project whose backbone was Matlab Software. He worked on Hierarchical Field Emitter Structure based on Copper nanowire and Carbon nanotubes during his M.Tech dissertation from IIT Roorkee in 2015.

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  Kanike Rajesh

  Mr. Kanike Rajesh, Research Scholar, Department of Metallurgical and Materials Engineering at Indian Institute of Technology, Roorkee. He obtained his Master Degree in Materials Technology at NIT Warangal in 2017 and B.Tech in Mechanical Engineering from Rajiv Gandhi University of Knowledge Technology RKValley, Andhrapradesh, India in 2014. His M.Tech Thesis work focused on the Studies on mechanical behaviour of polymer encapsulated and infiltrated cellular ceramic foams and has 1 publication from this work. He has received best paper presentation award at CSIR-IICT Hyderabad during his M.tech program. Presently, He is working on drug release metallic implant for Orthopaedic Applications.

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  Souvik Ghosh

  Souvik Ghosh, research scholar, Department of Biotechnology at Indian Institute of Technology, Roorkee. He received his M.Sc degree in Biological Science from Presidency University, Kolkata in 2015 and B.Sc degree in Zoology from Burdwan University, West Bengal in 2013. His M.Sc thesis work focused on Exploring Common Molecular Links between Leukemogenesis, Trans- Differentiation, & Tumor Reversion in Hematopoietic Cells. He has also worked in a DST-SERB sponsored project for one year as a Project fellow at Saha Institute of Nuclear Physics, Kolkata, West Bengal. The project was about the functional characterization of a zinc finger protein involved in nerve cell differentiation. His area of research interests are Cell Biology, Tissue engineering. Currently he is working in a project entitled "Developing polymer based scaffold with Electrical and Topographical cues for Neural Tissue Engineering".

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  Arabinda Majhi

  Mr. Arabinda Majhi, Research scholar, Department of Metallurgical and Materials Engineering at Indian Institute of Technology, Roorkee. He received his M. Tech degree in Materials Science and Engineering from IIT Kharagpur, West Bengal, in 2020, M.Sc. degree in Chemistry from IIT Guwahati, Assam in 2016 B.Sc. (Hons.) degree in Chemistry from The University of Burdwan, West Bengal in 2014. He also received B.Ed. Degree from Sidho-Kanho-Birsha University, Purulia, West Bengal in 2018. He completed his M.Tech project work on Hydrogel for Chemically Fueled Dissipative System and Sensing application. His M.Sc. project work focused on the Synthesis of Triazolyl Pyrene Unnatural C-Nucleoside and N-Nucleoside. Currently, he is working on developing polymer scaffolds for neuromuscular tissue regeneration.

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  Gunjan Kaushik

  Gunjan Kaushik is working as a Junior Research Fellow (JRF) in the project entitled “3D- Bio- stereolithography engineering functional tissues” at Dept. of Biotechnology, IIT Roorkee. She pursued M.Tech in Biomedical Engineering from the Centre of Biomedical Engineering (CBME), IIT Ropar, in 2020. She obtained her B.Sc and M.Sc degree in Life Sciences from the University of Rajasthan, Jaipur. Her M.Tech dissertation project focused on fabricating oligonucleotide loaded biodegradable hydrogel to improve diabetic wound healing. This hydrogel was intended to serve as an antimicrobial matrix and deliver the therapeutic agent at the wound site.

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  Krishnakant Phand

  Mr. Krishnakant Phand is a research scholar in the Metallurgical and Materials Engineering Department at IIT Roorkee. He completed his Bachelors in Mechanical Engineering in 2018 from Savitribai Phule Pune University and M.Tech in Material Science in 2021 from Defence Institute of Advanced Technology (DIAT), Pune. His M.Tech thesis work was focused on the fabrication of polymer nanocomposite based flexible piezoelectric energy harvesting devices. He has worked as a Production Planning and Control (PPC) Engineer at Maschio Gaspardo India Pvt Ltd. Pune.

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  Megha Dhiman

  Megha Dhiman, a research scholar, Centre for Nanotechnology at Indian Institute of Technology, Roorkee. She received her BS-MS dual degree with Chemistry majors from the Indian Institute of Science Education and Research (IISER), Mohali, in 2020. Her MS thesis work focused on the shape-controlled synthesis of Pd and core-shell Ag/Au nanostructures and their application in catalysis and biosensing. The current work is focused on developing biomaterial scaffolds for pancreatic tissue engineering.

M.Tech




BTech

Alumni

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  Dr. Vijyesh kumar

  Synthesis of boron nitride nanostructures and their potential application in composites, piezoelectric cells and bioimaging.

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  Dr. Murli K.

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  Dr. Manoj kumar

  Nano Filler Reinforced Polymer and Ceramics based Composite for Orthopedic and Structural Applications.

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  Dr. Ankita Bisht

  Carbon Nanofiller Modified Carbon Fiber Epoxy Composite For Structural Application.

• M.Tech

• Isha Goel, Jose Santo

• Jijo Christudas, Deepa Garg

• Akriti Sharma, Ketan Khamgaonkar, Bhagyadhar Das, Shubham Agrawal

• Mukul Kumar Srivastava

• Soumyaranjan Nayak, Sanjay Singh, Kishor Kumar Kuntal

• Sameer Chauksey, Pramanshu Trivedi

B.Tech

• Princi Vershwal, Gauri Chavan, Pragya Rani, Vrinda Sharma

• Praveen Gupta, Suvam Das, Rishabh Parihar, Dipu Ashok, Ananya Shrivastava, Pallavi Jha, Somesh Mohapatra

• Digant Ray

• Ashwani Jaiswal

• Akshat Mittal

• Manish Shekhar

• Prabhakar

• Jasjot

• Manohar

• Suyash

• Shravan Tickoo

• Mayank Aggarwal

• Ankita Gangrani

• Aditya Kumar

• Shubham Jain

• Prateek Sharma

• Dennis Dey

• Arnav Mittal

• Himanshu Garg

• Gopesh Kumar Gaurav

• Mahendra Singh Meena

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Our specific Research interests

1. Wound healing

• We aim at designing completely biodegradable scaffold that can provide the precise template for simultaneously regeneration of all the layers of skin without any need for completion surgery.
• Our scaffold designs are bio-inspired by the microarchitecture, physical and mechanical properties of skin tissue.
• The scaffold designs are also tailored to meet the specific requirements of specific types of wounds they are meant to heal.

Our Achievements

• Design and fabrication of a biomimetic smart regenerative scaffold for deep wounds
• Simultaneous regeneration of the entire skin with this scaffold without any skin grafting
• Scaffold microarchitecture, physical and mechanical properties resemble the skin tissue it heals
• Prototype for deep wound healing scaffold ready (Indian Patent Office - application number 201911007235)
• Prototype for severe burn wound healing scaffold ready (Indian Patent Office - application number 201911026834)

2. Temporary Fracture Fixing Accessories Orthopaedic Applications

• We aim at developing completely biodegradable magnesium based temporary fracture fixing accessories for orthopaedic application
• Mg-HA based composites developed at our laboratory has improved degradation and mechanical stability in simulated human body fluids when compare to pure Mg
• Our specific implant designs like differential HA layered composites (FGM) based on MG/HA have shown tremendous potential
• The problem of biomechanical stability of Mg-HA composites is also tailored

Our Achievements

• Design and fabrication of composites and FGM composites via conventional and spark plasma sintering
• Significant degradation and mechanical properties compared to natural human
• Biocompatibility in terms of cell adhesion , cell viability, protein adhesion and ALP activity has been achieved significantly
• The project was funded by DSTSB/SO/HS/138/2013
• Peer Review articles- 8
  No of PhD – 2
  M.Tech Thesis- 5

3. Drug Release Implant for Orthopedic Applications

• We aim at developing drug release orthopedic implants, which can prevent infection and maintains osteointegration with the bone simultaneously.
• Surface modification of acetabular cup liner (UHMWPE) and femoral stem have been done through chemical etching and plasma sprayed HA coating processes respectively, in order to create pores and impregnated with drug contained polymer.
• Implants have shown sustained drug release with excellent antibacterial activity, osteocompatablity and superior mechanical and tribological properties.

Our Achievements

• Development of polymer based drug eluting orthopedic implants project funded by DST India, Grant. No. SB/FTP/ETA-0184/2013.
• Surface modified metallic orthopedic implant for sustained drug release project funded by DST India, Grant. No. DST/TSG/AMT/2015/264/G.
• PhD’s: 2 ( one is completed and other pursuing).
• Articles: 6, Patents:1 (Indian patent no: 201711024735).
• Magazine on “Multifunctional Surface Treatment for Orthopedic Implant” has been published in medical health care times.

4. Neural Tissue Engineering

• Our group works on designing scaffold for peripheral nerve regeneration
• The existing neural scaffolds in clinical use and the ones reported in research papers provide only extra-cellular matrix and physical guidance for cell adhesion and axonal growth
• Provision for electrical guidance is not available with any scaffolds known so far
• Our studies are focused on improving cell adhesion and providing electrical guidance for axonal regeneration for which we are currently exploring different second phase reinforced polymeric matrices

Our Achievements

• Gupta et al., 2015, Carbon 95: 715-724
• Gupta et al., 2016, Neu. Reg. Res. 11: 1062-1063
• Gupta et al., 2019Materials Science & Engineering C 97: 539–551
• Shrivastava et al., Journal of tissue engineering and regenerative medicine (Under review)
• Ghosh et al., Biomaterial sciences (submitted)

5. Composite materials systems with nanofillers for Structural Applications