CELLULAR AND MOLECULAR IMMUNOLOGY LAB

Department of Biotechnology, IIT Roorkee

About Us

Research in our laboratory focuses on studying the key molecules, environmental and inter-cellular communication signals that modulate immune cell behavior and function under various life-threatening conditions such as systemic inflammation and cancer. One of the consequence of an inflammatory environment is the remodeling of extra cellular matrix proteins which could influence the immune via cell surface receptors such as integrins. Similarly, the complex and altered nature of cellular micro environments as seen in severe inflammation or cancer could modulate and reprogram cellular behavior. Our group is engaged in understanding various signals and resulting cellular dynamics using computational tools and techniques to understand the dynamics of receptor-ligand interactions, such as molecular docking, MD simulations and their validation in in-vitro and in-vivo experimental models.

Inflammation and Immunopathology

Immunooncology

Cancer Immunoediting

Extracellular Matrix and Immune Cell Interactions

Systems Immunology

Immunoinformatics

Achievements

Project Grants

Dr. Pranita P. Sarangi received grant from SERB, India and SATYAM, GoI (06 Feb 2021)

Media coverage

Our work was acknowledged by DBT, India. (25 Jan 2021)

Invited Talk

Dr. Pranita P Sarangi showcased her research work at International Professional Network conducted by NIH, USA

Discussion

Dr. Pranita P Sarangi among the panel discussion of EduTrek (1.0), SVNIT, Surat, India

Our Team

    •

Dr. Pranita P Sarangi

Associate Professor & PI

Research Interests: Immunooncology, Cancer immunoediting, Immunomodulatory therapeutics

    •

Pankaj Dipankar

SRF (ICMR)

M.Sc (Biotechnology)

Research Interests: Use of Computational Biology and Experimental validation in immunology

    •

Shiba Prasad Dash

SRF (UGC)

M.Sc (Biotechnology)

Research Interests: Immune cell trafficking in inflammation

    •

Nibedita Dalpati

SRF (CSIR)

M.Sc (Biotechnology)

Research Interests: Inflammatory signals in cancer

    •

Puneet Kumar

SRF (DBT-Project)

M.Tech (Biomedical Engineering)

Research Interests: Systems Immunology

    •

Saloni Gupta

JRF (CSIR)

M.Sc (Biotechnology)

Research Interests: Immuno-metabolism

Lab Almuni
  • Dr. Papiya Chakraborty (PhD awarded in 2020);
      Current Affiliation: Post-Doc at NIH, USA
  • Dr. Chandra Bhan (PhD awarded in 2019);
      Current Affiliation: Project Scientist, PGI Chandigarh, India

Publications

  • Dash SP, Dipankar P, Burange PS, *Rouse BT, *Sarangi PP. Climate Change: how it impacts the emergence, transmission, resistance and consequences Viral Infections in animals and plants. Critical Reviews in Microbiology (2021) *Corresponding author

  • #Dipankar P, #Kumar P, Dash SP, *Sarangi PP. Functional and Therapeutic Relevance of Rho GTPases in Innate Immune Cell Migration and Function During Inflammation: An In-silico perspective. Mediators of Inflammation (2021) #Co-First author *Corresponding author

  • Chakraborty P, Dash SP, Dalpati N, Kumar P, Jain D, *Sarangi PP. A C-terminal Fragment of Adhesion Protein Fibulin-7 Inhibits Growth of Murine Breast Tumor by Regulating macrophage reprogramming. The FEBS Journal (2020) *Corresponding author

    Highlighted in commentary in The FEBS journal

  • Chakraborty P, Dash SP, *Sarangi PP. The Role of Adhesion Protein Fibulin7 in Development and Diseases. Molecular Medicine (2020). *Corresponding author

  • Chakraborty P, Dalpati N, Bhan C, Dash SP, Kumar P, *Sarangi PP. A C-terminal fragment of adhesion protein Fibulin7 regulates neutrophil migration and functions and improves survival in LPS induced systemic inflammation. Cytokine (2020). *Corresponding author

  • Chakraborty P, Dipankar P, Dash SP, Priya, Srivastava S, Dhyani R, Navani NK, Sharma D, *Sarangi PP. Electrostatic Surface Potential of Macrophages Correlates with Their Functional Phenotype. Inflammation (2020) *Corresponding author

  • #Bhan C, #Dash SP, Dipankar P, Kumar P, Chakraborty P, *Sarangi PP. Investigation of extracellular matrix protein expression dynamics using murine models of systemic inflammation. Inflammation (2019). #First author *Corresponding author

  • #*Sarangi PP, #Chakraborty P, Dash SP, Ikeuchi T, de Vega S, Ambatipudi K, Wahl L, Yamada Y. Cell adhesion protein fibulin-7 and its C-terminal fragment negatively regulate monocyte and macrophage migration and functions in vitro and in vivo. The FASEB Journal. 2018 Apr 10;32(9):4889-98. #First author *Corresponding author

  • Sarangi PP, Lee HW, Lerman YV, Trzeciak A, Harrower EJ, Rezaie AR, Kim M. Activated protein C attenuates severe inflammation by targeting VLA-3 high neutrophil subpopulation in mice. The Journal of Immunology. 2017 Oct 15;199(8):2930-6.

  • Bhan C, Dipankar P, Chakraborty P, *Sarangi PP. Role of cellular events in the pathophysiology of sepsis. Inflammation Research. 2016 Nov 1;65(11):853-68.*Corresponding author

  • Lerman YV, Lim K, Hyun YM, Falkner KL, Yang H, Pietropaoli AP, Sonnenberg A, *Sarangi PP,*Kim M. Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α 3 β 1-dependent. Blood. 2014 Dec 4;124(24):3515-23.*Corresponding author

    Highlighted in commentary in The Blood journal

  • *Sarangi PP, Hyun YM, Lerman YV, Pietropaoli AP, Kim M. Role of β 1 integrin in tissue homing of neutrophils during sepsis. Shock (Augusta, Ga.). 2012 Aug;38(3):281.*Corresponding author

  • Hyun YM, Sumagin R, Sarangi PP, Lomakina E, Overstreet MG, Baker CM, Fowell DJ, Waugh RE, Sarelius IH, Kim M. Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. Journal of Experimental Medicine. 2012 Jul 2;209(7):1349-62.

  • Sarangi PP, Lee HW, Kim M. Activated protein C action in inflammation. British journal of haematology. 2010 Mar;148(6):817-33.

  • #Elphick GF, #Sarangi PP, Hyun YM, Hollenbaugh JA, Ayala A, Biffl WL, Chung HL, Rezaie AR, McGrath JL, Topham DJ, Reichner JS. Recombinant human activated protein C inhibits integrin-mediated neutrophil migration. Blood. 2009 Apr 23;113(17):4078-85. #First author

  • Sarangi PP, Woo SR, Rouse BT. 2009. Modulation of herpes virus induced ocular immunopathology by anti-CD200R:Fc treatment. Clinical Immunology. 131(1):31-40.

  • Sarangi PP, Rouse BT. Herpetic Keratitis. 2009. Levin and Albert Ocular Disease: Mechanisms and Management, Chapter 12, Elsevier. (Book Chapter)

  • Sarangi PP, Kim B, Rouse BT. 2008. Modulation of herpes virus induced ocular immunopathology by non-mitogenic anti-CD3 monoclonal antibody treatment. Investigative Ophthalmology & Visual Science. 49(12):5425-33.

  • Sarangi PP, Sehrawat S, Suvas S, Rouse BT. 2008. IL-10 and natural regulatory T cells: Two independent anti-inflammatory mechanisms in HSV induced ocular immunopathology. Journal of Immunology. 180(9):6297-306.

  • Sehrawat S, Suvas S, Sarangi PP, Shuryawanshi A, Rouse BT. 2008. In vitro generated antigen specific CD4+CD25+Foxp3+ regulatory T cells control the severity of virus induced immunoinflammatory lesion. Journal of Virology. 82(14):6838-51.

  • #Kim B, #Sarangi PP, Ahmet Kursat Azkur, Deshpande Kaistha S, Rouse BT. 2008. Enhanced viral immunoinflammatory lesions in mice lacking IL-23 responses. Microbes and infections. 10(3):302-312 #First author

  • Sarangi PP, Kim B., Kurt-Jones E, Rouse BT. 2007. Innate recognition network driving the HSV induced corneal immunopathology: Role of Toll Pathway in the early inflammatory events in Stromal Keratitis. Journal of Virology. 81(20):11128-38.

  • Kim B, Sarangi PP, Y Lee Deshpande Kaistha S, Lee S, Rouse BT. 2006. Depletion of MCP-1 increases development of herpetic stromal keratitis by innate immune modulation. Journal of Leukocyte Biology. 80(6):1405-15 Recommended in Faculty1000.

  • Kim B, Suvas S, Sarangi PP, Lee S, Reisfield RA, Rouse BT. 2006. Vascular endothelial growth factor receptor2-based DNA immunization delays development of herpetic stromal keratitis by antiangiogenic effects. Journal of Immunology. 177(6):4122-31.

  • Suvas S, Kim B, Sarangi PP, Tone M, Waldmann, H, Rouse BT. 2005. In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. Journal of Virology. 79(18):11935-42.

  • Rouse BT, Sarangi PP, Suvas S. 2006. Regulatory T cells in virus infections. Immunological Reviews. 212:272-86.

Conferences

  • Immunocon 2018, 1st-3rd Nov 2018, TISHTI, Faridabad, India

    Poster Presentation: Chakraborty P, Dipankar, P, Sarangi PP. Title: Evaluation of electrostatic surface charge distribution of inflammatory macrophages using zeta potential measurement as a tool.

  • Immunocon 2018, 1st-3rd Nov 2018, TISHTI, Faridabad, India

    Poster Presentation: Dipankar P, Chakraborty P, Sarangi PP. Title: Correlation of macrophage functional phenotypes with the electrostatic dynamics of surface proteins using in silico modeling approach.
  • Immunocon 2018, 1st-3rd Nov 2018, TISHTI, Faridabad, India

    Poster Presentation: Bhan C, Chakraborty P, Dalpati N, Dash SP, Dipankar P, Pranita P Sarangi. Title: Adhesion protein Fibulin7 modulates innate immune cell functions and improves survival in endotoxemia mice. Pg. 71

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Our Collaborators

We are proud to be associated with....

Dr. Barry T Rouse Professor at College of Veterinary Medicine, University of Tennessee, USA

Dr. Minsoo Kim Professor at School of Medicine and Dentistry, University of Rochester Medical Centre, USA

Dr. Kiran Ambatipudi Assistant Professor at Department of Biotechnology, IIT Roorkee, India

Dr. Umakanta Subudhi Scientist at CSIR-IMMT, India

Dr. Deepali Jain Associate Professor at Department of Pathology, AIIMS, India

Dr. Alok Mathur M.S. (General Surgery), SGRRU, India

Dr. Ram Kumar Verma M.S. (General Surgery), SGRRU, India

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